Female sex steroid induced epithelial changes in the gallbladder of the ovariectomized Syrian hamster.

Title

Female sex steroid induced epithelial changes in the gallbladder of the ovariectomized Syrian hamster.

Creator

Gilloteaux J; Karkare S; Ko W; Kelly T R

Publisher

Tissue & cell

Date

1992
1905-06

Description

Ovariectomized Syrian hamsters treated by female sex steroids during a 1-month period show gallbladder surface epithelial changes in the fundic area consistent with apical bulging and decapitations of the epithelial cells. These events were detected in the infundibulum and the fundic or body regions of estrogen- and estrogen+progesterone-treated hamsters. In control hamsters, these events were restricted to the region in the vicinity of the bile duct. Following steroid treatment, intraluminal deposits detected resembled Ca-bilirubinate deposits described in previous studies while decapitations are similar to endometrial epithelium changes associated with hormonal physiological changes or treatments. Moreover some small electron-dense deposits are comparable to those found in human cholesterol gallstones. This report indicates that, besides an alteration in bile composition, cell fragments originating from the surface epithelium of the bile duct and/or of the gallbladder mucosal epithelium could participate in gallstone nucleation.

Subject

Animals; Cholesterol; Cricetinae; Dietary/*administration & dosage; Electron; Epithelium/drug effects/ultrastructure; Estrogens/*adverse effects; Female; Gallbladder/*drug effects/ultrastructure; Mesocricetus; Microscopy; Ovariectomy; Ovary/*physiology; Progesterone/*adverse effects; Scanning

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

869–878

Issue

6

Volume

24

Citation

Gilloteaux J; Karkare S; Ko W; Kelly T R, “Female sex steroid induced epithelial changes in the gallbladder of the ovariectomized Syrian hamster.,” NEOMED Bibliography Database, accessed July 28, 2021, https://neomed.omeka.net/items/show/3313.

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