Serotonin contributes to the spinal antinociceptive effects of morphine.

Title

Serotonin contributes to the spinal antinociceptive effects of morphine.

Creator

Crisp T; Stafinsky J L; Uram M; Perni V C; Weaver M F; Spanos L J

Publisher

Pharmacology, biochemistry, and behavior

Date

1991
1991-07

Description

This study was designed to determine if morphine administered intrathecally (IT) interacts with serotonergic or noradrenergic nerve terminals in the spinal cord to produce analgesia on the spinally mediated tail-flick test. Male Sprague-Dawley rats were fitted with IT catheters. One week later, animals were spinally pretreated with receptor antagonists selective for opioid, serotonin or alpha-adrenoceptors, and the ability of these agents to alter spinal morphine-induced antinociception was assessed. Morphine dose-dependently elevated tail-flick latency in a naltrexone-reversible manner. The serotonin receptor antagonists spiroxatrine (5-HT1A), pindolol (5-HT1B), ritanserin (5-HT2) and ICS

Subject

Adrenergic alpha-Antagonists/pharmacology; Adrenergic Antagonists; Analgesics/*pharmacology; Animals; Biogenic Monoamines/physiology; Dose-Response Relationship; Drug; Inbred Strains; Injections; Male; Morphine/*pharmacology; Naltrexone/pharmacology; Nerve Endings/drug effects; Opioid/drug effects; Rats; Reaction Time; Receptors; Serotonin Antagonists/pharmacology; Serotonin/*physiology; Spinal; Spinal Cord/*drug effects

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

591–595

Issue

3

Volume

39

Citation

Crisp T; Stafinsky J L; Uram M; Perni V C; Weaver M F; Spanos L J, “Serotonin contributes to the spinal antinociceptive effects of morphine.,” NEOMED Bibliography Database, accessed July 30, 2021, https://neomed.omeka.net/items/show/3318.

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