Serotonergic mediation of cocaine seizures in mice.

Title

Serotonergic mediation of cocaine seizures in mice.

Creator

Schechter M D; Meehan S M

Publisher

Pharmacology, biochemistry, and behavior

Date

1995
1995-07

Description

We used genetically heterogeneous HS mice to investigate the effects of drugs that alter brain concentrations of serotonin on cocaine-induced convulsions and lethality. The racemer of fenfluramine, which increases synaptic serotonin, was coadministered with a dose (60 mg/kg, intraperitoneally) of cocaine that does not produce status epilepticus or death. This drug combination significantly increased the occurrence and decreased the time of onset of status epilepticus, but did not affect lethality. Likewise, 2.5 mg/kg of the D-isomer, of fenfluramine increased the occurrence of status epilepticus. Neither isomer effected lethality. When 2.5 mg/kg cinanserin, a drug that antagonizes postsynaptic serotonergic receptors, was coadministered with a higher (95 mg/kg) dose of cocaine, the time of onset of status epilepticus was significantly increased, whereas lethality was reduced. The results are discussed in light of the action of cocaine upon serotonin neurons and the relationship between seizurogenic activity and cocaine-induced lethality.

Subject

Animals; Brain Chemistry/drug effects; Cinanserin/pharmacology; Cocaine/*toxicity; Epilepsy; Female; Fenfluramine/pharmacology; Inbred Strains; Male; Mice; Seizures/chemically induced/*physiopathology; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/pharmacology; Serotonin/*physiology; Status Epilepticus/chemically induced/physiopathology; Tonic-Clonic/chemically induced/physiopathology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

313–316

Issue

2

Volume

51

Citation

Schechter M D; Meehan S M, “Serotonergic mediation of cocaine seizures in mice.,” NEOMED Bibliography Database, accessed October 18, 2021, https://neomed.omeka.net/items/show/3333.

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