Methods for studying the conductance changes associated with synaptic activation of forebrain slices: the interpretation of field potentials using CSD profiles.

Title

Methods for studying the conductance changes associated with synaptic activation of forebrain slices: the interpretation of field potentials using CSD profiles.

Creator

Borroni A M; Vaknin G; Berry R; Teyler T J

Publisher

Journal of neuroscience methods

Date

1991
1991-08

Description

In this report the cortical slice preparation and an array electrode that instantaneously records laminar field potentials are used to evaluate issues related to the interpretation of cortical CSD profiles. The major issues are: (1) what cell types are responsible for producing the source/sink pairs seen in CSD profiles; (2) what neurotransmitters are responsible for producing the sinks/sources seen in the CSD profile and do the sinks/sources reflect activation of receptors that produce inward currents, outward currents, or both; (3) can active and passive currents be distinguished; (4) do action potentials contribute to the CSD profile; and (5) can synaptic population with different kinetics and onset latencies be distinguished? Methods for analyzing neuronal circuits and analyzing CSDs quantitatively are discussed.

Subject

Animals; Evoked Potentials/drug effects/*physiology; Prosencephalon/*physiology; Synapses/*physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

89–102

Issue

1

Volume

39

Citation

Borroni A M; Vaknin G; Berry R; Teyler T J, “Methods for studying the conductance changes associated with synaptic activation of forebrain slices: the interpretation of field potentials using CSD profiles.,” NEOMED Bibliography Database, accessed May 13, 2021, https://neomed.omeka.net/items/show/3339.

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