The development of GABAB-mediated activity in the rat dentate gyrus.

Title

The development of GABAB-mediated activity in the rat dentate gyrus.

Creator

DiScenna P G; Nowicky A V; Teyler T J

Publisher

Brain research. Developmental brain research

Date

1994
1994-02

Description

We examined the effects of GABAB receptor activation in the dentate gyrus of hippocampal slices prepared from 6-8-day-old rat pup. Baclofen (0.25-1.0 microM), a GABAB agonist, rapidly and potently disinhibited the developing dentate, similar to its effect in the mature organism. CGP 35348, a GABAB antagonist, quickly reversed the baclofen-induced disinhibition. However, GABAB antagonists did not reverse long-latency (500-1000 ms IPI) paired-pulse depression, suggesting that it is not caused by a late GABAB-mediated IPSP. GABAB-mediated disinhibition of the dentate gyrus can occur by postnatal day 6, providing a powerful mechanism for altering excitability in the developing hippocampus.

Subject

Animals; Baclofen/analogs & derivatives/pharmacology; Electric Stimulation; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; GABA-A/drug effects/physiology; GABA-B Receptor Antagonists; GABA-B/*metabolism; Hippocampus/*growth & development/*metabolism; In Vitro Techniques; Organophosphorus Compounds/pharmacology; Rats; Receptors

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

295–298

Issue

2

Volume

77

Citation

DiScenna P G; Nowicky A V; Teyler T J, “The development of GABAB-mediated activity in the rat dentate gyrus.,” NEOMED Bibliography Database, accessed May 8, 2021, https://neomed.omeka.net/items/show/3343.

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