Prenatal cocaine exposure leads to enhanced long-term potentiation in region CA1 of hippocampus.

Title

Prenatal cocaine exposure leads to enhanced long-term potentiation in region CA1 of hippocampus.

Creator

Little J Z; Teyler T J

Publisher

Brain research. Developmental brain research

Date

1996
1996-03

Description

Cocaine use by pregnant women is currently of concern for its social and economic impact. Clinical studies of cocaine exposed offspring are limited by methodological constraints. In this study we used a rabbit model to examine the effects of gestational cocaine exposure on substrates of learning and memory. Rabbits, 30 to 40 days old, were examined for alterations in synaptic plasticity using an intact hippocampal slice preparation. Extracellular recordings revealed in utero cocaine exposure predisposed slices to larger long-term potentiation compared to controls.

Subject

*Prenatal Exposure Delayed Effects; Animals; Cocaine/*administration & dosage/pharmacology; Electrophysiology; Female; Hippocampus/*drug effects/physiology; In Vitro Techniques; Long-Term Potentiation/*drug effects; Narcotics/*administration & dosage/pharmacology; Neuronal Plasticity/drug effects; Pregnancy; Rabbits; Reference Values; Synapses/drug effects

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

117–119

Issue

1

Volume

92

Citation

Little J Z; Teyler T J, “Prenatal cocaine exposure leads to enhanced long-term potentiation in region CA1 of hippocampus.,” NEOMED Bibliography Database, accessed December 2, 2021, https://neomed.omeka.net/items/show/3344.

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