Age related changes of social memory/recognition in male Fischer 344 rats.

Age related changes of social memory/recognition in male Fischer 344 rats.

Guan X; Dluzen D E

Behavioural brain research

1994

1994-03

Two different habituation-dishabituation test paradigms were used to evaluate differences in social memory/recognition among 3-, 15- and 22-month-old male Fischer 344 rats. For test 1, males received three 2-min exposures to the same stimulus ovariectomized female, followed by three 2-min exposures to a different stimulus female with an inter-trial interval of 6 min. All groups showed a habituation response with investigation times decreasing on trials 2 and 3. Introduction of a different stimulus female on trial 4 (dishabituation) resulted in significant differences with investigation times of the 3-month animals being significantly greater than both the 15- and 22-month animals and those of the 15- being greater than the 22-month animals. Notably, the 22-month-old animals failed to dishabituate on this task. For test 2, all animals received two trials with different stimulus females used in each trial. While investigation times of the

*Social Behavior; Aging/*physiology; Animal/physiology; Animals; Arousal/physiology; Female; Habituation; Inbred F344; Male; Mental Recall/*physiology; Psychophysiologic/*physiology; Psychophysiology; Rats; Retention (Psychology)/physiology; Sexual Behavior; Social Environment

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