Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.
Title
Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.
Creator
Calcagnetti D J; Schechter M D
Publisher
Progress in neuro-psychopharmacology & biological psychiatry
Date
1993
1993-07
Description
1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats conditioned with 16 or 32 micrograms doses of CATH significantly increased the time spent in their less preferred side, whereas rats conditioned with the 8.0 micrograms dose failed to show any shift from baseline preference. The 16 and 32 micrograms doses of CATH also significantly (p \textless .004) increased activity by more than 65% of baseline. 2. Exp. 2 was designed to determine whether ICV pretreatment with a dopamine release inhibitor CGS 10746B (CGS; 15 micrograms/rat) would block place conditioning produced by CATH. The results demonstrate that CGS pretreatment effectively blocked CATH-induced place conditioning and the CATH-induced elevation of activity.
Subject
*Dopamine Antagonists; Alkaloids/administration & dosage/*pharmacology; Animals; Antipsychotic Agents/pharmacology; Central Nervous System Stimulants/administration & dosage/*pharmacology; Conditioning; Discrimination (Psychology)/drug effects; Dose-Response Relationship; Drug; Injections; Intraventricular; Male; Operant/*drug effects; Rats; Sprague-Dawley; Thiazepines/pharmacology
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Calcagnetti D J; Schechter M D, “Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.,” NEOMED Bibliography Database, accessed April 23, 2024, https://neomed.omeka.net/items/show/3357.