Differential training sequence effect upon psychostimulant discrimination.

Differential training sequence effect upon psychostimulant discrimination.

Schechter M D

Progress in neuro-psychopharmacology & biological psychiatry

1993

1993-03

1. Previous studies indicate that rats trained to discriminate either cathinone or cathine from its vehicle have a diminished discriminative performance when tested 24 hours after a drug administration when compared to tests conducted after a vehicle administration. The phenomenon of rapid tolerance may occur to produce a lessened interceptive cue on the test day following administration of the drug. It would, therefore, be probable that when rats are trained with consecutive cathinone or cathine administrations they would perform less well than if they were trained with these drugs never given in consecutive training sessions. 2. To test this hypothesis, rats were trained with 0.8 mg/kg

Alkaloids/pharmacology; Animals; Appetite Depressants/pharmacology; Central Nervous System Stimulants/*pharmacology; Discrimination Learning/*drug effects; Dose-Response Relationship; Drug; Food; Male; Phenylpropanolamine/pharmacology; Psychotropic Drugs/pharmacology; Rats; Reinforcement Schedule; Sprague-Dawley

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

319–327

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