Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus.

Title

Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus.

Creator

Grover L M; Teyler T J

Publisher

Neuroscience letters

Date

1993
1993-05

Description

Conditioning stimulation of afferent fibers in hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of responses evoked by stimulation of an independent set of afferent fibers. PTD was present within 5 s of conditioning stimulation, amounted to a 60-80% reduction of excitatory postsynaptic potentials (EPSPs), and required a period of 3-5 min for recovery. Antagonists of A1 adenosine receptors substantially reduced PTD. Adenosine released into, or formed in, the extracellular space during conditioning stimulation may diffuse within the slice to depress evoked release of glutamate.

Subject

Adenosine/*physiology; Afferent/drug effects/physiology; Animals; Dendrites/drug effects/physiology; Electric Stimulation; Evoked Potentials/drug effects/physiology; Hippocampus/cytology/drug effects/*physiology; In Vitro Techniques; Neuronal Plasticity/drug effects/physiology; Neurons; Purinergic Antagonists; Rats; Synapses/drug effects/*physiology; Synaptic Transmission/drug effects/physiology; Theophylline/analogs & derivatives/pharmacology; Xanthines/pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

39–42

Issue

1

Volume

154

Citation

Grover L M; Teyler T J, “Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus.,” NEOMED Bibliography Database, accessed June 25, 2021, https://neomed.omeka.net/items/show/3365.

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