In utero cocaine exposure decreases dopamine D1 receptor modulation of hippocampal long-term potentiation in the rabbit.

Title

In utero cocaine exposure decreases dopamine D1 receptor modulation of hippocampal long-term potentiation in the rabbit.

Creator

Little J Z; Teyler T J

Publisher

Neuroscience letters

Date

1996
1996-09

Description

Cocaine increases the synaptic concentration of neurotransmitters by inhibiting catecholamine transporters. Disturbances of behavior and cellular physiology have been associated with prenatal cocaine exposure and are related to changes in dopamine transmission. Recently we found the magnitude of long-term potentiation (LTP) was greater in hippocampal slices from cocaine exposed offspring. In the hippocampus, D1 dopamine receptor antagonists inhibit the expression of LTP while agonists facilitate it. To test the functionality of the D1 receptor we examined the effect of the D1 antagonist SCH-23390 on LTP using a rabbit model of gestational cocaine exposure. Tetanization during exposure to the D1 antagonist

Subject

Animals; Cocaine/*pharmacology; Dopamine D1/*drug effects; Female; Hippocampus/*drug effects; Long-Term Potentiation/*drug effects; Rabbits; Receptors; Uterus/*drug effects

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

157–160

Issue

3

Volume

215

Citation

Little J Z; Teyler T J, “In utero cocaine exposure decreases dopamine D1 receptor modulation of hippocampal long-term potentiation in the rabbit.,” NEOMED Bibliography Database, accessed October 22, 2021, https://neomed.omeka.net/items/show/3367.

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