In utero cocaine exposure decreases dopamine D1 receptor modulation of hippocampal long-term potentiation in the rabbit.
Title
In utero cocaine exposure decreases dopamine D1 receptor modulation of hippocampal long-term potentiation in the rabbit.
Creator
Little J Z; Teyler T J
Publisher
Neuroscience letters
Date
1996
1996-09
Description
Cocaine increases the synaptic concentration of neurotransmitters by inhibiting catecholamine transporters. Disturbances of behavior and cellular physiology have been associated with prenatal cocaine exposure and are related to changes in dopamine transmission. Recently we found the magnitude of long-term potentiation (LTP) was greater in hippocampal slices from cocaine exposed offspring. In the hippocampus, D1 dopamine receptor antagonists inhibit the expression of LTP while agonists facilitate it. To test the functionality of the D1 receptor we examined the effect of the D1 antagonist SCH-23390 on LTP using a rabbit model of gestational cocaine exposure. Tetanization during exposure to the D1 antagonist
Subject
Animals; Cocaine/*pharmacology; Dopamine D1/*drug effects; Female; Hippocampus/*drug effects; Long-Term Potentiation/*drug effects; Rabbits; Receptors; Uterus/*drug effects
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Little J Z; Teyler T J, “In utero cocaine exposure decreases dopamine D1 receptor modulation of hippocampal long-term potentiation in the rabbit.,” NEOMED Bibliography Database, accessed February 17, 2025, https://neomed.omeka.net/items/show/3367.