A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.

Title

A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.

Creator

Keck B J; Stafinsky J L; Uram M; Crisp T

Publisher

General pharmacology

Date

1995
1995-01

Description

1. Male Sprague-Dawley rats were chronically tested with intrathecal (i.t.) receptor selective opioid antagonists to determine if antinociceptive supersensitivity developed to selective i.t. opioid receptor agonists. 2. A subcutaneously implanted osmotic minipump was used to deliver the mu-opioid receptor antagonist CTOP (0.3 nmol) or the delta-opioid receptor antagonist naltrindole (5.5 nmol) for 7 days. 3. Following a 24 hr washout period, rats received a single i.t. dose (ED50) of either DAMPGO (for CTOP-treated animals) or DPDPE (for naltrindole-treated animals) and the antinociceptive effects of the agents were tested on the tail-flick test. 4. Our findings revealed that chronic spinal treatment with selective opioid receptor antagonists did not induce an antinociceptive supersensitivity to selective opioid receptor agonists. 5. Perhaps this lack of supersensitivity is reflective of difficulties inherent to opioid receptor antagonists that do not possess negative intrinsic activity.

Subject

5)-; Ala(2)-MePhe(4)-Gly(5)-; Animals; D-Penicillamine (2; Dose-Response Relationship; Drug; Enkephalin; Enkephalins/*pharmacology; Male; Naltrexone/analogs & derivatives/pharmacology; Narcotic Antagonists/*pharmacology; Opioid/*drug effects; Rats; Receptors; Somatostatin/analogs & derivatives/pharmacology; Species Specificity; Spinal Cord/*drug effects; Sprague-Dawley

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

161–168

Issue

1

Volume

26

Citation

Keck B J; Stafinsky J L; Uram M; Crisp T, “A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.,” NEOMED Bibliography Database, accessed January 28, 2021, https://neomed.omeka.net/items/show/3369.

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