Premorbid behaviors produced by cocaine, ethanol and cocaethylene in the mouse.

Title

Premorbid behaviors produced by cocaine, ethanol and cocaethylene in the mouse.

Creator

Meehan S M; Schechter M D

Publisher

General pharmacology

Date

1995
1995-01

Description

1. The premorbid behaviors produced by the administration of cocaine, ethanol, their combination, as well as a metabolite produced by their co-administration, viz. cocaethylene, were defined, determined and quantified in the HS strain of mice. 2. The LD50 for ethanol was 9.71 g/kg in males and 9.45 g/kg in females, whereas the LD50 values in male and female mice for cocaine were 101.55 and 90.00 mg/kg, respectively. 3. The data indicate that clonic-tonic seizures continued into status epilepticus after cocaine administration and prior to cocaine-induced lethality. In contrast, administration of the cocaine-ethanol metabolite cocaethylene produced status epilepticus without producing clonic-tonic seizures yet still resulted in lethality. 4. Thus, both cocaine and cocaethylene may produce their lethal effects in mice through neuro-regulatory mechanisms mediating protracted seizure induction.

Subject

Animal/*drug effects; Animals; Behavior; Cocaine/*analogs & derivatives/*toxicity; Dose-Response Relationship; Drug; Ethanol/*toxicity; Female; Lethal Dose 50; Male; Mice

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

99–106

Issue

1

Volume

26

Citation

Meehan S M; Schechter M D, “Premorbid behaviors produced by cocaine, ethanol and cocaethylene in the mouse.,” NEOMED Bibliography Database, accessed October 28, 2021, https://neomed.omeka.net/items/show/3370.

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