Pentobarbital differentially inhibits N-methyl-D-aspartate and kainate-stimulated [3H]noradrenaline overflow in rat cortical slices.

Pentobarbital differentially inhibits N-methyl-D-aspartate and kainate-stimulated [3H]noradrenaline overflow in rat cortical slices.

Brown L M

General pharmacology

1995

1995-11

1. This study examined the ability of pentobarbital to inhibit NMDA and kainate-stimulated [3H]noradrenaline ([3H]NA) overflow in rat brain cortical slices. 2. Pentobarbital inhibited NMDA-evoked [3H]NA overflow at 100 microM and greater and inhibited kainate-evoked [3H]NA overflow at 10 microM and greater. 3. The ability of pentobarbital to inhibit concentration-response curves for NMDA and kainate-evoked overflow of [3H]NA were also examined. Pentobarbital (300 microM) caused a 20% reduction in NMDA and a 50% reduction in kainate-induced maximal responses.

*Excitatory Amino Acid Agonists; Adrenergic alpha-Agonists/metabolism; Animals; GABA Modulators/*pharmacology; Kainic Acid/*antagonists & inhibitors; Male; N-Methylaspartate/*antagonists & inhibitors; Norepinephrine/metabolism; Pentobarbital/*pharmacology; Prefrontal Cortex/*drug effects; Rats; Sprague-Dawley

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