N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: input-specific induction and preclusion in a non-tetanized pathway.

N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: input-specific induction and preclusion in a non-tetanized pathway.

Grover L M; Teyler T J

Neuroscience

1992

1992-07

We previously reported that an N-methyl-D-aspartate receptor-independent component of long-term potentiation with an apparent delayed onset can be induced in area CA1 of the hippocampus. Here we show that some but not all of this delay in onset can be accounted for by a transient heterosynaptic depression. We also show that N-methyl-D-aspartate receptor-independent long-term potentiation is induced only in the input pathway tetanized, and not in a second pathway. However, prior induction of N-methyl-D-aspartate receptor-independent long-term potentiation in one pathway precludes later induction in an independent pathway. Calcium entry through dihydropyridine-sensitive Ca2+ channels may be a critical step for induction of N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 [Grover L. M. and Teyler T.J. (1990) Nature 347,

2-Amino-5-phosphonovalerate/*pharmacology; Animals; Electron; Evoked Potentials/drug effects; Hippocampus/*physiology; In Vitro Techniques; Microscopy; N-Methyl-D-Aspartate/*physiology; N-Methylaspartate/*pharmacology; Pyramidal Tracts/drug effects/*physiology; Rats; Receptors; Time Factors

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

7–11

1

49