Increases in the locomotor activity of rats after intracerebral administration of cathinone.

Title

Increases in the locomotor activity of rats after intracerebral administration of cathinone.

Creator

Calcagnetti D J; Schechter M D

Publisher

Brain research bulletin

Date

1992
1992-12

Description

There is a widespread practice among people living in Eastern Africa and Southern Arabia of chewing the leaves of the Khat shrub so as to produce pharmacological effects that are practically indistinguishable from those produced by amphetamine (AMPH). Cathinone (CATH) has been identified as the psychostimulant constituent of this plant and, although the locomotor elevating effects of centrally administered AMPH and cocaine (COC) in rats are well known, there is a paucity of data regarding CATH. Three experiments were, therefore, conducted to measure locomotor activity following central administration of CATH in rats. The first experiment determined the dose-dependent effects of CATH on activity following intracerebroventricular (ICV) administration. As psychostimulant effects are believed, at least in part, to be mediated by dopaminergic systems, in Experiment 2 CATH was injected into the dopamine nerve terminals of the nucleus accumbens. Experiment 3 examined the effects of CATH injection into the dopamine cell body region of the substantia nigra, and activity was measured. Results of the ICV injection of CATH revealed a dose-dependent increase of activity. The highest dose tested (64 micrograms) yielded a 117% increase in activity when compared to baseline, whereas a 20 micrograms bilateral nucleus accumbens (NA) injection of CATH increased activity fivefold. These findings evidence the hypothesis that the effects of CATH are dopaminergically mediated. Substantia nigra (SN) injections of CATH were without effect.

Subject

Alkaloids/administration & dosage/*pharmacology; Animals; Cerebral Ventricles/drug effects/*physiology; Dose-Response Relationship; Drug; Injections; Intraventricular; Male; Motor Activity/*drug effects; Nucleus Accumbens/drug effects/*physiology; Psychotropic Drugs/administration & dosage/*pharmacology; Rats; Sprague-Dawley; Stereotaxic Techniques; Substantia Nigra/drug effects/*physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

843–846

Issue

6

Volume

29

Citation

Calcagnetti D J; Schechter M D, “Increases in the locomotor activity of rats after intracerebral administration of cathinone.,” NEOMED Bibliography Database, accessed June 23, 2021, https://neomed.omeka.net/items/show/3373.

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