Ethanol-produced interoceptive stimuli are time dependent in selectively bred HAS and LAS rats.

Title

Ethanol-produced interoceptive stimuli are time dependent in selectively bred HAS and LAS rats.

Creator

Schechter M D

Publisher

Alcohol (Fayetteville, N.Y.)

Date

1992
1992-04

Description

Fourteenth generation high alcohol-sensitive (HAS) and low alcohol-sensitive (LAS) rats were trained to discriminate the effects of 600 mg/kg intraperitoneally administered ethanol from its vehicle at 6 and 30 min postadministration. Each of the earlier- and later-trained animals were given lower doses of ethanol and ED50 values at their trained postadministration interval were found to be nonsignificantly different. Thus, there was no difference between HAS and LAS animals as to their sensitivity to the discriminative effects of ethanol. Phase-generalization studies, where rats trained at 6 min postadministration were tested with the drug at 30 min postadministration were shown not to generalize, whereas the animals trained at 30 min postadministration and tested at 6 min postinjection were shown to readily discriminate the discriminative stimuli. This asymmetrical generalization lends evidence to the biphasic action of ethanol, and suggests that the earlier phase is quantitatively different than the latter phase. The similarity in sensitivity of the LAS and HAS animals, furthermore, suggests that the discrimination of ethanol is not based on its hypnotic effects.

Subject

*Discrimination Learning; Animals; Dose-Response Relationship; Drug; Drug Tolerance; Ethanol/administration & dosage/*pharmacology; Male; Rats; Time Factors

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

117–122

Issue

2

Volume

9

Citation

Schechter M D, “Ethanol-produced interoceptive stimuli are time dependent in selectively bred HAS and LAS rats.,” NEOMED Bibliography Database, accessed May 15, 2021, https://neomed.omeka.net/items/show/3383.

Social Bookmarking