Locomotor activity but not conditioned place preference is differentially affected by a moderate dose of ethanol administered to P and NP rats.

Locomotor activity but not conditioned place preference is differentially affected by a moderate dose of ethanol administered to P and NP rats.

Schechter M D

Alcohol (Fayetteville, N.Y.)

1992

1992-06

The conditioned place preference (CPP) test and spontaneous motor activity were used in order to determine if ethanol-preferring (P) rats differ from ethanol nonpreferring (NP) rats after the administration of a moderate (1.0 g/kg) dose of ethanol. Results indicate that both of the selectively bred lines of rats found ethanol aversive, with little difference between the P and the NP rats. In contrast, the NP rats were shown to be more sensitive to the motor-impairing effect of ethanol.

*Alcohol Drinking; *Environment; Animals; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Male; Motor Activity/*drug effects; Mutant Strains; Rats; Reinforcement (Psychology)

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

185–188

3

9