Multimodal drugs and their future for Alzheimer's and Parkinson's disease.

Title

Multimodal drugs and their future for Alzheimer's and Parkinson's disease.

Creator

Van der Schyf Cornelis J; Geldenhuys Werner J

Publisher

International review of neurobiology

Date

2011
1905-07

Description

This chapter discusses the rationale for developing multimodal or multifunctional drugs (also called designed multiple ligands or DMLs) aimed at disease-modifying treatment strategies for the most common neurodegenerative diseases Alzheimer's and Parkinson's disease (AD and PD). Both the prevalence and incidence of AD and PD have seen consistent and dramatic increases, a disconcerting phenomenon which, ironically, has been attributed to extended life expectancy brought about by better health care globally. In spite of these statistics, the development and introduction to the clinic of new therapies proven to prevent or delay the onset of AD and PD have been disappointing. Evidence has accumulated to suggest that the etiopathology of these diseases is extremely complex, with an array of potential drug targets located within a number of deleterious biochemical pathways. Therefore, in these diseases, it is unlikely that the complex pathoetiological cascade leading to disease initiation or progression will be mitigated by any one drug acting on a single pathway or target. The pursuit of novel DMLs may offer far better outcomes. Although certainly not the only, and perhaps not even the best, approach but farthest along the drug development pipeline in the DML paradigm are drugs that combine inhibition of monoamine oxidase with associated etiological targets unique to either AD or PD. These compounds will constitute the major focus of this chapter, which will also explore radically new paradigms that seek to combine cognitive enhancers with proneurogenesis compounds.

Subject

Alzheimer Disease/*drug therapy/*enzymology/prevention & control; Animals; Combined Modality Therapy/*methods; Forecasting; Humans; Monoamine Oxidase Inhibitors/*pharmacology/therapeutic use; Parkinson Disease/*drug therapy/*enzymology/prevention & control

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

107–125

Volume

100

Citation

Van der Schyf Cornelis J; Geldenhuys Werner J, “Multimodal drugs and their future for Alzheimer's and Parkinson's disease.,” NEOMED Bibliography Database, accessed June 20, 2021, https://neomed.omeka.net/items/show/3393.

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