Carboplatin and paclitaxel for the treatment of advanced or recurrent endometrial cancer.

Title

Carboplatin and paclitaxel for the treatment of advanced or recurrent endometrial cancer.

Creator

Akram Tahira; Maseelall Priya; Fanning James

Publisher

American journal of obstetrics and gynecology

Date

2005
2005-05

Description

OBJECTIVE: The purpose of this study was to determine the activity and toxicity of carboplatin and paclitaxel (taxol) in the treatment of advanced or recurrent endometrial cancer. STUDY DESIGN: This was a retrospective review of 18 consecutive patients with advanced (stage 4) or recurrent endometrial adenocarcinoma that had been treated with outpatient carboplatin and taxol. Taxol was delivered at 135 mg/m 2 over 3 hours, and carboplatin was delivery at an area under the curve of 5 over 1 hour. Cycles were repeated every 21 days. RESULTS: The overall response rate was 63% with 28% of patients who had a partial response and 35% of patients who had a complete response. Kaplan-Meier test was used to estimate the median survival time of 27 months and the median progression free survival time of 24 months. No patient had neutropenia, thrombocytopenia or grade 3 vomiting, neurosensory toxicity, or renal toxicity. CONCLUSION: Carboplatin and taxol for the treatment of advanced or recurrent endometrial cancer appear to be active regimens with minimal toxicity.

Subject

Adult; Aged; Antineoplastic Agents; Antineoplastic Agents/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/*therapeutic use; Carboplatin/administration & dosage; Drug Administration Schedule; Endometrial Neoplasms/*drug therapy; Female; Humans; Local/drug therapy; Middle Aged; Neoplasm Recurrence; Paclitaxel/administration & dosage; Phytogenic/administration & dosage; Survival Analysis; Treatment Outcome

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1365–1367

Issue

5

Volume

192

Citation

Akram Tahira; Maseelall Priya; Fanning James, “Carboplatin and paclitaxel for the treatment of advanced or recurrent endometrial cancer.,” NEOMED Bibliography Database, accessed March 28, 2024, https://neomed.omeka.net/items/show/3436.