Methodological optimization of tinnitus assessment using prepulse inhibition of the acoustic startle reflex.

Title

Methodological optimization of tinnitus assessment using prepulse inhibition of the acoustic startle reflex.

Creator

Longenecker R J; Galazyuk A V

Publisher

Brain research

Date

2012
2012-11

Description

Recently prepulse inhibition of the acoustic startle reflex (ASR) became a popular technique for tinnitus assessment in laboratory animals. This method confers a significant advantage over the previously used time-consuming behavioral approaches utilizing basic mechanisms of conditioning. Although this technique has been successfully used to assess tinnitus in different laboratory animals, many of the finer details of this methodology have not been described enough to be replicated, but are critical for tinnitus assessment. Here we provide detail description of key procedures and methodological issues that provide guidance for newcomers with the process of learning to correctly apply gap detection techniques for tinnitus assessment in laboratory animals. The major categories of these issues include: refinement of hardware for best performance, optimization of stimulus parameters, behavioral considerations, and identification of optimal strategies for data analysis. This article is part of a Special Issue entitled: Tinnitus Neuroscience.

Subject

Acoustic Stimulation/instrumentation/*methods; Animal/physiology; Animals; Behavior; Habituation; Mice; Psychophysiologic/physiology; Reflex; Startle/*physiology; Tinnitus/*diagnosis/physiopathology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

54–62

Volume

1485

Citation

Longenecker R J; Galazyuk A V, “Methodological optimization of tinnitus assessment using prepulse inhibition of the acoustic startle reflex.,” NEOMED Bibliography Database, accessed May 14, 2021, https://neomed.omeka.net/items/show/3509.

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