The role of type I interferons and other cytokines in dermatomyositis.

Title

The role of type I interferons and other cytokines in dermatomyositis.

Creator

Arshanapalli Ashish; Shah Mihir; Veerula Vindhya; Somani Ally-Khan

Publisher

Cytokine

Date

2015
2015-06

Description

Much work has been done to unveil the mechanisms behind the pathogenesis of dermatomyositis (DM) - mainly those involving certain pathogenic cytokines, termed "pathokines" as the principal cytokines involved. Recently, it has become clear that a group of cytokines known as type I interferons (IFN-Is) play a significant role in the development of DM. We review the literature published between 1946 and 2014 using an Ovid Medline database search to provide an update on the role of IFN-Is and other cytokines in the pathogenesis of DM. We provide information about the genes and proteins induced by IFN-Is and potential mechanisms by which these downstream products relate to clinical disease activity. We also explore findings of other autoimmune phenomena that may contribute to disease onset and activity including T-helper 17 (Th17) cells and associated interleukins, as well as autoantibodies. Finally, we provide a brief update on current treatment options for DM as well as some new immunomodulatory treatment modalities in development.

Subject

Autoantibodies/immunology; Biological; Cytokines; Dermatomyositis; Dermatomyositis/*immunology/physiopathology/therapy; Humans; Inflammatory myopathy; Interferon Type I/*metabolism; Models; Pathogenesis; Signal Transduction; Type I interferons

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

319–325

Issue

2

Volume

73

Citation

Arshanapalli Ashish; Shah Mihir; Veerula Vindhya; Somani Ally-Khan, “The role of type I interferons and other cytokines in dermatomyositis.,” NEOMED Bibliography Database, accessed June 19, 2021, https://neomed.omeka.net/items/show/3544.

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