Assessment of alkoxylphenacyl-based polycarbonates as a potential platform for controlled delivery of a model anti-glaucoma drug.

Assessment of alkoxylphenacyl-based polycarbonates as a potential platform for controlled delivery of a model anti-glaucoma drug.

Manickavasagam Dharani; Wehrung Daniel; Chamsaz Elaheh A; Sanders Matthew; Bouhenni Rachida; Crish Samuel D; Joy Abraham; Oyewumi Moses O

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2016

2016-10

Treatment strategies for glaucoma will benefit from injectable and/or implantable delivery systems that can achieve sustained delivery of neuroprotective agents (to the posterior segment) and/or intraocular pressure lowering drugs (to the anterior segment). In this regard, we have evaluated the suitability of a new polymer (alkoxylphenacyl-based polycarbonates copolymer with polycaprolactone;

*Models; Animals; Brimonidine tartrate; Drug delivery; Glaucoma/*drug therapy; Humans; Nanoparticles; Ocular microfilms; Polycarboxylate Cement/*therapeutic use; Rats; Sustained release; Theoretical

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56–66

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