Hepatoid carcinoma of the ovary: A case report and review of the literature.

Title

Hepatoid carcinoma of the ovary: A case report and review of the literature.

Creator

Randolph Laura K; Hopkins Maeve K; Hopkins Michael P; Wasdahl Daniel A

Publisher

Gynecologic oncology reports

Date

2015
2015-08

Description

Primary hepatoid carcinoma of the ovary (HCO) is a rare aggressive tumor that typically presents at an advanced stage in postmenopausal women with unilateral or bilateral ovarian masses and elevated AFP and CA125. We report a case of HCO in a 73 year-old woman who presented with abdominal distention, weight loss, and a large lower abdominal mass. Postoperative serum AFP was markedly elevated and trended down with initiation of chemotherapy. Review of the literature revealed thirty-two reported cases with no consensus on histogenesis or consistent immunohistochemical profile other than positive AFP staining in all but one case. Although the optimal treatment has not yet been determined, tumor debulking surgery followed by a platinum and taxane based chemotherapy regimen has shown promise. Both serum AFP and CA125 appear to have prognostic value and can be used to follow response to treatment and screen for recurrence.

Subject

Alpha-fetoprotein; Hepatoid ovarian carcinoma

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

64–67

Volume

13

Citation

Randolph Laura K; Hopkins Maeve K; Hopkins Michael P; Wasdahl Daniel A, “Hepatoid carcinoma of the ovary: A case report and review of the literature.,” NEOMED Bibliography Database, accessed June 30, 2022, https://neomed.omeka.net/items/show/3576.

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