DISC: Describing Infections of the Spine treated with Ceftaroline.

DISC: Describing Infections of the Spine treated with Ceftaroline.

Watkins Richard R; Yendewa George; Burdette Steven D; Horattas Sophia; Haller Nairmeen Awad; Mangira Caroline; Salata Robert A; Bonomo Robert A

Journal of global antimicrobial resistance

2018

2018-06

OBJECTIVES: Infections of the spine lead to considerable morbidity and a high cost to the global healthcare system. Currently, evidence for using ceftaroline, an advanced-generation cephalosporin active against methicillin-resistant Staphylococcus aureus (MRSA), in spine infections is limited. METHODS: Describing Infections of the Spine treated with Ceftaroline (DISC) is a multicentre, retrospective, cohort study that evaluated ceftaroline for treating spine infections. Patients were included if they were aged \textgreater/=18 years, diagnosed with a spine infection and treated with ceftaroline for \textgreater/=28 days. A control group was identified with the same inclusion criteria as the study population except they were treated with a comparator antibiotic for \textgreater/=28 days. RESULTS: Thirty-seven patients were included each in the ceftaroline and control groups. MRSA was the most commonly identified pathogen. With no differences between groups in age, sex, race or co-morbidities (with the exception of chronic kidney disease), treatment with ceftaroline led to similar clinical success compared with the control group. Multivariate regression analysis did not show a significant difference between the two groups in terms of clinical success after controlling for other covariates (adjusted odds ratio=1.49; P=0.711). More patients who received ceftaroline were discharged to an extended-care or rehabilitation facility than home compared with controls (81% vs. 54%, respectively; P=0.024). Side effects and toxicities were rare, including one case of eosinophilic pneumonia in the ceftaroline group. CONCLUSIONS: Ceftaroline appears to be a safe and effective therapy for infections of the spine, including from MRSA.

Ceftaroline; Discitis; Epidural abscess; MRSA; Vertebral osteomyelitis

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