Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery.

Title

Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery.

Creator

Fanning James; Murrain Luis; Flora Robert; Hutchings Timothy; Johnson Jil M; Fenton Bradford W

Publisher

Journal of minimally invasive gynecology

Date

2007
2007-10

Description

STUDY OBJECTIVE: To perform the original phase I/II trial of autologous platelet tissue graft in gynecologic surgery to evaluate toxicity and efficacy on decreasing pain. DESIGN: Prospective nonrandomized trial (Canadian Task Force classification II-A). SETTING: Teaching hospital. PATIENTS: Fifty-five consecutive patients undergoing major gynecologic surgery were entered into this prospective phase I/II trial and were matched with 55 patients from the previous 6 months. INTERVENTION: After anesthesia was induced, peripheral venous blood (55 mL) was obtained from the patient producing, autologous platelet tissue graft (20 mL). At completion of surgery, autologous platelet tissue graft was directly applied to the surgical site. MEASUREMENTS AND MAIN RESULTS: Median pain on the day of surgery was 2.7 (mild) in the autologous platelet tissue graft group vs 6.7 (severe) in the control group, p \textless.001. Likewise, pain on postoperative day 1 was 2.1 (mild) in the autologous platelet tissue graft group vs 5.5 (moderate) in the control group, p \textless or =.001. Median of morphine per hospital stay for the autologous platelet tissue graft group was 17 mg (range 1-98 mg) vs 26 mg (range

Subject

80 and over; Adult; Aged; Autologous/*adverse effects/methods; Case-Control Studies; Female; Gynecologic Surgical Procedures/adverse effects/*methods; Humans; Middle Aged; Pain; Pain Measurement; Platelet-Rich Plasma/*physiology; Postoperative/*therapy; Transplantation

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

633–637

Issue

5

Volume

14

Citation

Fanning James; Murrain Luis; Flora Robert; Hutchings Timothy; Johnson Jil M; Fenton Bradford W, “Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery.,” NEOMED Bibliography Database, accessed January 27, 2021, https://neomed.omeka.net/items/show/3665.

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