Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation.

Title

Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation.

Creator

Sadana Prabodh; Coughlin Lucy; Burke Jamie; Woods Robert; Mdzinarishvili Alexander

Publisher

Journal of the neurological sciences

Date

2015
2015-07

Description

The use of neuroprotective strategies to mitigate the fatal consequences of ischemic brain stroke is a focus of robust research activity. We have previously demonstrated that thyroid hormone (T3; 3,3',5-triiodo-l-thyronine) possesses neuroprotective and anti-edema activity in pre-stroke treatment regimens when administered as a solution or as a nanoparticle formulation. In this study we have extended our evaluation of thyroid hormone use in animal models of brain stroke. We have used both transient middle cerebral artery occlusion (t-MCAO) and permanent (p-MCAO) models of ischemic brain stroke. A significant reduction of tissue infarction and a concurrent decrease in edema were observed in the t-MCAO model of brain stroke. However, no benefit of T3 was observed in p-MCAO stroke setting. Significant improvement of neurological outcomes was observed upon T3 treatment in t-MCAO mice. Further, we tested T2 (3,5-diiodo-l-thyronine) a natural deiodination metabolite of T3 in MCAO model of brain stroke. T2 potently decreased infarct size as well as edema formation. Additionally, we report here that T3 suppresses the expression of aquaporin-4 (AQP4) water channels which could be a likely mechanism of its anti-edema activity. Our studies provide evidence to stimulate clinical development of thyroid hormones for use in ischemic brain stroke.

Subject

Animals; Aquaporin 4/*physiology; Aquaporin-4; Brain Edema/*drug therapy/pathology; Cerebral edema; Cerebrovascular Circulation/drug effects/physiology; Diiodothyronines/*administration & dosage; Erythropoietin; Infarction; Injections; Intravenous; Ischemic brain stroke; Male; Mice; Middle cerebral artery occlusion (MCAO); Middle Cerebral Artery/*drug therapy/pathology; Stroke/*drug therapy/pathology; Thyroid hormone; Triiodothyronine/*administration & dosage

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

37–45

Issue

1

Volume

354

Citation

Sadana Prabodh; Coughlin Lucy; Burke Jamie; Woods Robert; Mdzinarishvili Alexander, “Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation.,” NEOMED Bibliography Database, accessed July 28, 2021, https://neomed.omeka.net/items/show/3669.

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