Bile acid metabolism and signaling in liver disease and therapy.

Title

Bile acid metabolism and signaling in liver disease and therapy.

Creator

Chiang John Y L

Publisher

Liver research

Date

2017
2017-06

Description

Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5). Agonist activation of FXR and TGR5 improves insulin and glucose sensitivity and stimulates energy metabolism to prevent diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD). Bile acids have both pro- and anti-inflammatory actions through FXR and TGR5 in the intestine and liver. In the intestine, bile acids activate FXR and TGR5 to stimulate stimulate fibroblast growth factor 15 and glucagon-like peptide-1 secretion. FXR and TGR5 agonists may have therapeutic potential for treating liver-related metabolic diseases, such as diabetes and NAFLD.

Subject

Bile acid metabolism; Cholestatic liver; diseases Metabolic diseases

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

3–9

Issue

1

Volume

1

Citation

Chiang John Y L, “Bile acid metabolism and signaling in liver disease and therapy.,” NEOMED Bibliography Database, accessed April 11, 2021, https://neomed.omeka.net/items/show/3697.

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