Trianthema portulacastrum Linn. exerts chemoprevention of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats.

Trianthema portulacastrum Linn. exerts chemoprevention of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats.

Bishayee Anupam; Mandal Animesh

Mutation research

2014

2014-10

Due to limited treatment options for advanced-stage metastatic breast cancer, a high priority should be given to develop non-toxic chemopreventive drugs. The value of various natural and dietary agents to reduce the risk of developing breast cancer is well established. Trianthema portulacastrum Linn. (Aizoaceae), a dietary and medicinal plant, has been found to exert antihepatotoxic and antihepatocarcinogenic properties in rodents. This study was initiated to investigate mechanism-based chemopreventive potential of an ethanolic extract of T. portulacastrum (TPE) against 7,12-dimethylbenz(a)anthracene (DMBA)-initiated rat mammary gland carcinogenesis, an experimental tumor model that closely resembles human breast cancer. Rats had access to a basal diet supplemented with TPE to yield three dietary doses of the extract, i.e., 50, 100 and 200 mg/kg body weight. Following two weeks of TPE treatment, mammary tumorigenesis was initiated by oral administration of DMBA (50 mg/kg body weight). At the end of the study (16 weeks after DMBA exposure), TPE exhibited a striking reduction of

*Dietary Supplements; *Mammary Neoplasms; 10-Dimethyl-1; 2-benzanthracene/*toxicity; 9; Aizoaceae/*chemistry; Animals; Apoptosis; Bax; Bcl-2; bcl-2-Associated X Protein/metabolism; beta-Catenin; Breast cancer; Carcinogens/*toxicity; Cell proliferation; Cell Proliferation/drug effects; Chemoprevention; Cyclin D1; DMBA; Experimental/chemically induced/metabolism/pathology/prevention & control; Humans; Male; Medicinal/*chemistry; Phytotherapy/*methods; Plants; Proliferating Cell Nuclear Antigen/metabolism; Rats; Sprague-Dawley; Trianthema portulacastrum; Up-Regulation/drug effects; Wnt Signaling Pathway/drug effects

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