Parity decreases methamphetamine-induced striatal dopaminergic perturbation.

Parity decreases methamphetamine-induced striatal dopaminergic perturbation.

Dluzen Dean E

Neurochemistry international

2011

2011-08

The role of parity upon methamphetamine-induced neurotoxicity of the striatal dopaminergic system was assessed. Female CD-1 mice either remained nulliparous or underwent one or three complete pregnancies and were designated as the 0, 1 or 3 pregnancy groups. The mice were then treated with a neurotoxic regimen of methamphetamine (MA–40 mg/kg) or its saline vehicle (control) and striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels were measured at

*Parity; Animals; Corpus Striatum/*drug effects/metabolism/physiology; Dopamine/*metabolism; Female; Methamphetamine/*pharmacology; Mice; Pregnancy

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101–103

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