Testosterone enhances dopamine depletion by methamphetamine in male, but not female, mice.

Title

Testosterone enhances dopamine depletion by methamphetamine in male, but not female, mice.

Creator

Lewis Chandani; Dluzen Dean E

Publisher

Neuroscience letters

Date

2008
2008-12

Description

We examined the effects of varying concentrations of testosterone propionate (T) treatment within intact and gonadectomized male and female mice with regard to its capacity to alter striatal dopamine (DA) depletion in response to a neurotoxic regimen of methamphetamine (MA). Administration of T at 24h prior to MA significantly increased striatal DA depletion in intact and gonadectomized male mice. Similar treatments administered to intact and gonadectomized female mice failed to alter striatal DA concentrations in response to MA. These results demonstrate that T can enhance MA-induced neurotoxicity in male, but not in female, mice. Such findings have important implications with regard to sex differences in nigrostriatal dopaminergic function, in general, and, in specific, to sex differences related to nigrostriatal dopaminergic neurotoxicity and neurodegeneration like that in response to MA and in Parkinson's disease, where a greater incidence is typically reported for males.

Subject

*Sex Characteristics; Animals; Castration/methods; Corpus Striatum/drug effects/metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Dose-Response Relationship; Drug; Female; Male; Methamphetamine/*pharmacology; Mice; Testosterone Propionate/*pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

130–133

Issue

1

Volume

448

Citation

Lewis Chandani; Dluzen Dean E, “Testosterone enhances dopamine depletion by methamphetamine in male, but not female, mice.,” NEOMED Bibliography Database, accessed October 15, 2021, https://neomed.omeka.net/items/show/3712.

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