Synaptic activity-induced Ca(2+) signaling in avian cochlear nucleus magnocellularis neurons.

Synaptic activity-induced Ca(2+) signaling in avian cochlear nucleus magnocellularis neurons.

Wang Lie-Cheng; Tang Zheng-Quan; Lu Yong

Neuroscience research

2012

2012-02

Neurons of the avian cochlear nucleus magnocellularis (NM) receive glutamatergic inputs from the spiral ganglion cells via the auditory nerve and feedback GABAergic inputs primarily from the superior olivary nucleus. We investigated regulation of Ca(2+) signaling in NM neurons with ratiometric Ca(2+) imaging in chicken brain slices. Application of exogenous glutamate or GABA increased the intracellular Ca(2+) concentration ([Ca(2+)](i)) in NM neurons. Interestingly,

Animals; Calcium Signaling/*physiology; Chick Embryo; Chickens; Cochlear Nucleus/*metabolism; GABA-A/metabolism; Inhibitory Postsynaptic Potentials/physiology; Neurons/*metabolism; Organ Culture Techniques; Patch-Clamp Techniques; Receptors; Synapses/*metabolism; Synaptic Transmission/*physiology

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

129–139

2

72