Aging and sex differences in striatal dopaminergic function.

Aging and sex differences in striatal dopaminergic function.

McDermott J L; Dluzen D E

Neuroscience

2007

2007-10

In this report the potassium- (30 mM) and amphetamine- (10 microM) stimulated responses of dopamine (DA) and 3,4-dihydroxy phenylacetic acid (DOPAC) from superfused striatal tissue of female and male mice as sampled at 2, 6, 18 and 24 months of age were compared. When assessed relative to responses obtained from

3; 4-Dihydroxyphenylacetic Acid/metabolism; Aging/*physiology; Amphetamine/pharmacology; Animals; Chemical; Dopamine Uptake Inhibitors/pharmacology; Dopamine/metabolism/*physiology; Female; In Vitro Techniques; Male; Mice; Neostriatum/metabolism/*physiology; Organ Size/physiology; Potassium/pharmacology; Sex Characteristics; Stimulation; Uterus/physiology

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