Metabotropic glutamate receptors in auditory processing.

Title

Metabotropic glutamate receptors in auditory processing.

Creator

Lu Y

Publisher

Neuroscience

Date

2014
2014-08

Description

As the major excitatory neurotransmitter used in the vertebrate brain, glutamate activates ionotropic and metabotropic glutamate receptors (mGluRs), which mediate fast and slow neuronal actions, respectively. Important modulatory roles of mGluRs have been shown in many brain areas, and drugs targeting mGluRs have been developed for the treatment of brain disorders. Here, I review studies on mGluRs in the auditory system. Anatomical expression of mGluRs in the cochlear nucleus has been well characterized, while data for other auditory nuclei await more systematic investigations at both the light and electron microscopy levels. The physiology of mGluRs has been extensively studied using in vitro brain slice preparations, with a focus on the lower auditory brainstem in both mammals and birds. These in vitro physiological studies have revealed that mGluRs participate in neurotransmission, regulate ionic homeostasis, induce synaptic plasticity, and maintain the balance between excitation and inhibition in a variety of auditory structures. However, very few in vivo physiological studies on mGluRs in auditory processing have been undertaken at the systems level. Many questions regarding the essential roles of mGluRs in auditory processing still remain unanswered and more rigorous basic research is warranted.

Subject

Animals; Auditory Pathways/anatomy & histology/physiology; Auditory Perception/*physiology; auditory processing; excitotoxicity; Humans; Metabotropic Glutamate/*metabolism; mGluR; neuromodulation; neurotransmission; Receptors; synaptic plasticity

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

429–445

Volume

274

Citation

Lu Y, “Metabotropic glutamate receptors in auditory processing.,” NEOMED Bibliography Database, accessed March 6, 2021, https://neomed.omeka.net/items/show/3747.

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