Pharmacological modulation of acute trauma memories to prevent PTSD: considerations from a developmental perspective.

Title

Pharmacological modulation of acute trauma memories to prevent PTSD: considerations from a developmental perspective.

Creator

Hruska Bryce; Cullen Patrick K; Delahanty Douglas L

Publisher

Neurobiology of learning and memory

Date

2014
2014-07

Description

Estimates of the lifetime prevalence of posttraumatic stress disorder (PTSD) in American adults range from 6.4% to 6.8%. PTSD is associated with increased risk for comorbid major depression, substance use disorder, suicide, and a variety of other mental and physical health conditions. Given the negative sequelae of trauma/PTSD, research has focused on identifying efficacious interventions that could be administered soon after a traumatic event to prevent or reduce the subsequent incidence of PTSD. While early psychosocial interventions have been shown to be relatively ineffective, early (secondary) pharmacological interventions have shown promise. These pharmacological approaches are largely based on the hypothesis that disruption of altered stress hormone levels and the consequent formation of trauma memories could protect against the development of PTSD. The present manuscript reviews the literature regarding the role of peri-traumatic stress hormones as risk factors for the development of PTSD and reviews evidence for the efficacy of exogenously modulating stress hormone levels to prevent/buffer the development of PTSD symptoms. Whereas prior literature has focused primarily on either child or adult studies, the present review incorporates both child and adult studies in a developmental approach to understanding risk for PTSD and how pharmacological modulation of acute memories may buffer the development of PTSD symptoms.

Subject

*Memory; Adrenergic beta-Antagonists/*pharmacology; Adult; Animals; Child; Cortisol; Developmental; Episodic; Humans; Hydrocortisone; Hydrocortisone/*biosynthesis/therapeutic use; Hypothalamo-Hypophyseal System/*metabolism; Pituitary-Adrenal System/*metabolism; Post-Traumatic/*metabolism/prevention & control; Posttraumatic stress disorder; Propranolol; Propranolol/*pharmacology; Stress Disorders; Sympathetic Nervous System/*metabolism; Trauma memories

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

122–129

Volume

112

Citation

Hruska Bryce; Cullen Patrick K; Delahanty Douglas L, “Pharmacological modulation of acute trauma memories to prevent PTSD: considerations from a developmental perspective.,” NEOMED Bibliography Database, accessed December 8, 2021, https://neomed.omeka.net/items/show/3750.

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