Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial.

Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial.

Chow Ronald; Ding Keyue; Ganesh Vithusha; Meyer Ralph M; van der Linden Yvette M; Roos Daniel; Hartsell William F; Hoskin Peter; Wu Jackson S Y; Nabid Abdenour; van Acht Manouk; Wanders Rinus; Babington Scott; Demas William F; Wilson Carolyn F; Wong Rebecca K S; Brundage Michael; Zhu Liting; Chow Edward

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2018

2018-03

BACKGROUND AND PURPOSE: Patient's gender and age may influence physicians in prescribing palliative radiotherapy. The purpose of this secondary analysis of the National Cancer Institute of Canada Clinical Trials Group Symptom Control Trial SC.20 was to explore the gender and age differences in pain and patient reported outcomes in cancer patients with bone metastases undergoing re-irradiation. MATERIALS AND METHODS: Response to radiation was evaluated using the International Bone Metastases Consensus Endpoint Definitions. Patients completed the Brief Pain Inventory (BPI) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (C30) before and 2months after re-irradiation. RESULTS: A total of 847 patients were analyzed. At baseline, men had more dyspnea, and mild pain. Older patients consumed less analgesic. More women reported clinically significant improvement in mood and enjoyment of life in the BPI after radiation. Similarly, younger patients reported better improvement in enjoyment of life. There were no significant gender or age differences in overall survival, response to radiation, or in C30 scores at 2months. CONCLUSION: Similar benefit in terms of pain relief was observed across all patient groups. Cancer patients with bone metastases should be offered palliative re-irradiation irrespective of gender or age. TRIAL REGISTRATION: NCT00080912; https://clinicaltrials.gov/ct2/show/NCT00080912.

*Age; *Bone metastases; *Gender; *Pain response; *Quality of life; *Radiotherapy; *Re-irradiation; Age Factors; Aged; Bone Neoplasms/physiopathology/*radiotherapy/*secondary; Cancer Pain/etiology/*radiotherapy; Female; Humans; Male; Middle Aged; Pain Measurement; Palliative Care/methods/statistics & numerical data; Patient Reported Outcome Measures; Physicians'/*statistics & numerical data; Practice Patterns; Quality of Life; Re-Irradiation; Sex Factors

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