Unconventional effects of estrogen uncovered.

Title

Unconventional effects of estrogen uncovered.

Creator

Dluzen Dean E

Publisher

Trends in pharmacological sciences

Date

2005
2005-10

Description

The nigrostriatal dopamine system shows marked gender differences that, in many cases, can be attributable to estrogen. However, the virtual absence of conventional estrogen receptors within the nigrostriatal dopamine system has made it difficult to understand how estrogen can function within this system. Recent findings have helped to uncover how estrogen can affect a discrete function of striatal dopamine-containing neurons–transporter activity–in a manner similar to that achieved through alterations in dopamine D(2) receptors and their associated G protein. These findings suggest that the effects of estrogen on dopamine transporter function could result from a signal transduction interaction involving D(2) receptor-G protein coupling.

Subject

Animals; Corpus Striatum/*metabolism/physiology; Dopamine D2/metabolism; Dopamine/*metabolism; Estrogens/*physiology; GTP-Binding Proteins/metabolism; Humans; Receptors; Signal Transduction/physiology; Substantia Nigra/*metabolism/physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

485–487

Issue

10

Volume

26

Citation

Dluzen Dean E, “Unconventional effects of estrogen uncovered.,” NEOMED Bibliography Database, accessed July 13, 2024, https://neomed.omeka.net/items/show/3799.