The effect of testosterone upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.

Title

The effect of testosterone upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.

Creator

Gao X; Dluzen D E

Publisher

Brain research

Date

2001
2001-02

Description

The gonadal steroid hormone estrogen (E) can function as a neuroprotectant of nigrostriatal dopaminergic (NSDA) neurotoxicity, however, there exists very limited information on the role of testosterone (T) in this capacity. In the present report, the effects of T on methamphetamine (MA) induced neurotoxicity of the NSDA system were examined in gonadectomized female and male CD-1 mice. In Experiment 1, striatal dopamine (DA) concentrations and output from T-treated ovariectomized mice were not significantly different from that of non-T-treated mice following MA. These results suggest that T is not functioning as a modulator of MA-induced NSDA neurotoxicity in ovariectomized CD-1 mice. In Experiment 2, there were no significant differences in DA concentrations or output among

Subject

Animals; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism; Drug Implants; Female; Male; Methamphetamine/*toxicity; Mice; Neuroprotective Agents/pharmacology; Neurotoxins/*toxicity; Orchiectomy; Ovariectomy; Potassium/pharmacology; Substantia Nigra/drug effects/*metabolism; Testosterone/administration & dosage/*pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

63–69

Issue

1

Volume

892

Citation

Gao X; Dluzen D E, “The effect of testosterone upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.,” NEOMED Bibliography Database, accessed February 25, 2021, https://neomed.omeka.net/items/show/3834.

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