Gender and the behavioral manifestations of neuropathic pain.

Title

Gender and the behavioral manifestations of neuropathic pain.

Creator

Tall J M; Stuesse S L; Cruce W L; Crisp T

Publisher

Pharmacology, biochemistry, and behavior

Date

2001
2001-01

Description

A model of peripheral nerve injury was used to study gender differences in the development and progression of chronic constriction injury (CCI)-induced hyperalgesia and allodynia in male and female Fischer 344 FBNF1 hybrid rats. Rats were randomly assigned to one of the following treatment groups: (1) gonadally intact unligated males (male); (2) gonadally intact ligated males (male (CCI)); (3) castrated ligated males (male (CAS/CCI)); (4) gonadally intact unligated females (female); (5) gonadally intact ligated females (female (CCI)); and (6) ovariectomized ligated females (female (OVX/CCI)). A plantar analgesia meter and calibrated von Frey pressure filaments were used as the analgesiometric assays. In the absence of nerve injury, gonadally intact males responded significantly faster than females to a thermal nociceptive stimulus. The onset of the behavioral manifestations of unilateral ligation of the sciatic nerve did not differ as a function of sex or hormonal status (e.g., gonadally intact and gonadectomized male and female rats developed thermal hyperalgesia within 14 days post-CCI). Paw withdrawal latency (PWL) values of gonadally intact males returned to baseline control values after postligation day 14, whereas gonadally intact females, ovariectomized females and castrated males continued to elicit robust thermal hyperalgesic symptoms throughout the 35-day duration of the experiment. Allodynic responses to peripheral nerve injury were less variable across genders. These data suggest that the mechanisms underlying chronic nociceptive processing differ as a function of gender and gonadal hormone status.

Subject

*Peripheral Nerve Injuries; Animal/*physiology; Animals; Behavior; Female; Gonadal Steroid Hormones/pharmacology; Hyperalgesia/psychology; Inbred F344; Male; Orchiectomy; Ovariectomy; Pain Measurement/drug effects; Pain Threshold/drug effects; Pain/etiology/*psychology; Rats; Sex Characteristics

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

99–104

Issue

1

Volume

68

Citation

Tall J M; Stuesse S L; Cruce W L; Crisp T, “Gender and the behavioral manifestations of neuropathic pain.,” NEOMED Bibliography Database, accessed April 15, 2021, https://neomed.omeka.net/items/show/3872.

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