MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats.

MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats.

Schechter M D

Pharmacology, biochemistry, and behavior

1998

1998-02

A two-lever, food-motivated, operant technique was employed to train the purportedly serotonergically dysfunctional Fawn-Hooded (FH) rat to discriminate 1.5 mg/kg MDMA. Once all 10 male subjects learned the MDMA-vehicle discrimination at criterion performance level, doses different than the training dose were used to generate a dose-response discrimination gradient. The ED50 value of MDMA was shown to be 0.136 mg/kg, not significantly different from that of previously trained Sprague-Dawley male rats. Thus, the Fawn-Hooded rat appears to not differ in its sensitivity to lower doses of MDMA. Testing for MDMA-like stimulus generalizations with other drugs indicated that the MDMA derivative MDE produced generalization at a dose of 2.25 mg/kg and allowed for an ED50 value of 0.496 mg/kg. Like MDE, the testing of alpha-ethyltryptamine was shown to produce

4-methylenedioxyamphetamine/*pharmacology; Animals; Central Nervous System Stimulants/*pharmacology; Conditioning; Cues; Discrimination (Psychology)/drug effects; Dopamine Agents/pharmacology; Dose-Response Relationship; Drug; Generalization; Hallucinogens/*pharmacology; Inbred Strains; Male; N-Methyl-3; Operant/drug effects; Rats; Serotonin Agents/pharmacology; Serotonin/genetics/physiology; Sprague-Dawley; Stimulus/drug effects

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

265–270

2

59