Strain differences in neuropathic hyperalgesia.

Title

Strain differences in neuropathic hyperalgesia.

Creator

Lovell J A; Stuesse S L; Cruce W L; Crisp T

Publisher

Pharmacology, biochemistry, and behavior

Date

2000
2000-01

Description

The purpose of this study was to investigate strain-related differences in the onset and maintenance of thermal hyperalgesia following the induction of peripheral nerve injury in two inbred strains of rats (Fischer 344 and Lewis) and two outbred strains of rats (Sprague-Dawley and Wistar). Neuropathic pain was induced via unilateral ligation of the left sciatic nerve with chromic gut sutures. A plantar analgesia meter was used to measure paw-withdrawal latency from the ligated vs. unligated hind paws of inbred vs. outbred strains of rats to investigate strain-related differences in nerve injury-induced thermal hyperalgesia. The results demonstrated no significant effects of animal strain on presurgical paw-withdrawal latency values. Following the sciatic nerve ligation (SNL) surgery, a significant hyperalgesic response was elicited from the Sprague-Dawley and Wistar rats (outbred strains) for at least 28 days. Conversely, data analyses from the inbred strains failed to demonstrate significant hyperalgesic responses to peripheral nerve injury, with the exception of postsurgical day 10. These data emphasize the importance of considering the strain of the rat being investigated before extrapolating the results from animals experiments to treatment strategies for humans with chronic neuropathic pain.

Subject

Animals; Chronic Disease; Cytokines/physiology; Hyperalgesia/*etiology; Inbred F344; Inbred Lew; Ligation; Male; Rats; Sciatic Nerve/physiology; Species Specificity; Sprague-Dawley; Wistar

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

141–144

Issue

1

Volume

65

Citation

Lovell J A; Stuesse S L; Cruce W L; Crisp T, “Strain differences in neuropathic hyperalgesia.,” NEOMED Bibliography Database, accessed August 1, 2021, https://neomed.omeka.net/items/show/3878.

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