Why adult mammalian intrafusal and extrafusal fibers contain different myosin heavy-chain isoforms.

Title

Why adult mammalian intrafusal and extrafusal fibers contain different myosin heavy-chain isoforms.

Creator

Walro J M; Kucera J

Publisher

Trends in neurosciences

Date

1999
1999-04

Description

Multiple isoforms of the contractile protein myosin are present in mammalian skeletal muscles. The diversity of the heavy-chain subunits of myosin (MyHCs) in intrafusal fibers is thought to reflect a pathway of differentiation that is unique to muscle spindles. In fact, intrafusal MyHCs are developmental isoforms expressed by the prenatal precursors of both intrafusal and extrafusal fibers. In adult limbs, developmental MyHCs persist in intrafusal, but not extrafusal fibers principally due to the afferent neurons that arrest their maturational replacement by MyHCs associated with faster shortening velocities. The slow shortening velocities that are characteristic of developmental MyHCs might be adaptive for precise calibration of muscle spindles as sense organs.

Subject

*Muscle Development; Afferent Pathways/physiology; Aging/metabolism; Animals; Cell Lineage; Developmental; Fetal Proteins/metabolism; Gene Expression Regulation; Knockout; Mammals/anatomy & histology/*metabolism; Mice; Morphogenesis; Muscle; Muscle Contraction; Muscle Fibers; Muscle Proteins/deficiency/physiology; Muscle Spindles/physiology; Myosin Heavy Chains/*metabolism; Nerve Tissue Proteins/deficiency/physiology; Protein Isoforms/*metabolism; Rats; Skeletal/*chemistry/classification; Skeletal/chemistry/embryology/*growth & development/ultrastructure; Transgenic

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

180–184

Issue

4

Volume

22

Citation

Walro J M; Kucera J, “Why adult mammalian intrafusal and extrafusal fibers contain different myosin heavy-chain isoforms.,” NEOMED Bibliography Database, accessed October 18, 2021, https://neomed.omeka.net/items/show/3886.

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