Olfactory bulb norepinephrine depletion abolishes vasopressin and oxytocin preservation of social recognition responses in rats.

Olfactory bulb norepinephrine depletion abolishes vasopressin and oxytocin preservation of social recognition responses in rats.

Dluzen D E; Muraoka S; Landgraf R

Neuroscience letters

1998

1998-10

Male rats were implanted bilaterally with cannulae directed at the olfactory bulbs and infused with either vehicle or 6-OHDA to selectively deplete norepinephrine concentrations at this site. At 5-7 days following this treatment, these animals received a bilateral infusion of either arginine vasopressin (AVP) or oxytocin (OXT) through these same guide cannulae and were then tested for their capacity to maintain social recognition responses. Neither infusion of AVP nor OXT were able to preserve recognition responses in the animals treated with

*Social Behavior; Animals; Arginine Vasopressin/administration & dosage/*pharmacology; Infusions; Male; Norepinephrine/*physiology; Olfactory Bulb/drug effects/*physiology; Oxidopamine/administration & dosage/pharmacology; Oxytocin/administration & dosage/*pharmacology; Parenteral; Rats; Time Factors; Wistar

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