Two components of long-term potentiation induced by different patterns of afferent activation.

Title

Two components of long-term potentiation induced by different patterns of afferent activation.

Creator

Grover L M; Teyler T J

Publisher

Nature

Date

1990
1990-10

Description

Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA1 and dentate gyrus) and neocortex. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.

Subject

2-Amino-5-phosphonovalerate/*pharmacology; Afferent Pathways/physiology; Animals; Calcium/*physiology; Hippocampus/*physiology; In Vitro Techniques; Membrane Potentials; Memory/*physiology; N-Methyl-D-Aspartate/*physiology; Neuronal Plasticity; Receptors; Synaptic Transmission; Time Factors

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

477–479

Issue

6292

Volume

347

Citation

Grover L M; Teyler T J, “Two components of long-term potentiation induced by different patterns of afferent activation.,” NEOMED Bibliography Database, accessed May 6, 2021, https://neomed.omeka.net/items/show/3978.

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