Members of the novel UBASH3/STS/TULA family of cellular regulators suppress

Members of the novel UBASH3/STS/TULA family of cellular regulators suppress

Newman Tiffanny N; Liverani Elisabetta; Ivanova Elitza; Russo Gian L; Carpino Nick; Ganea Doina; Safadi Fayez; Kunapuli Satya P; Tsygankov Alexander Y

Immunology and cell biology

2014

2014-11

The UBASH3/STS/TULA family consists of two members sharing substantial homology and a similar multi-domain architecture, which includes a C-terminal histidine phosphatase domain capable of dephosphorylating phosphotyrosine-containing substrates. TULA-family proteins act as downregulators of receptor-induced activation in several cell types, including T cells and platelets. Deletion of both family members in mice has been shown to result in hyperresponsiveness of T cells to T-cell receptor (TCR)/CD3 complex engagement, but little is known about the biological consequences of double knockout (dKO) and especially of either single KO (sKO). We elucidated the biological consequences of the lack of

Animals; Antigen; Colitis/*immunology; Humans; Knockout; Mice; Phosphorylation; Protein Tyrosine Phosphatases/genetics/*physiology; Receptors; T-Cell/genetics/*physiology; T-Lymphocytes/*immunology; ZAP-70 Protein-Tyrosine Kinase/metabolism

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837–850

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