Members of the novel UBASH3/STS/TULA family of cellular regulators suppress

Title

Members of the novel UBASH3/STS/TULA family of cellular regulators suppress

Creator

Newman Tiffanny N; Liverani Elisabetta; Ivanova Elitza; Russo Gian L; Carpino Nick; Ganea Doina; Safadi Fayez; Kunapuli Satya P; Tsygankov Alexander Y

Publisher

Immunology and cell biology

Date

2014
2014-11

Description

The UBASH3/STS/TULA family consists of two members sharing substantial homology and a similar multi-domain architecture, which includes a C-terminal histidine phosphatase domain capable of dephosphorylating phosphotyrosine-containing substrates. TULA-family proteins act as downregulators of receptor-induced activation in several cell types, including T cells and platelets. Deletion of both family members in mice has been shown to result in hyperresponsiveness of T cells to T-cell receptor (TCR)/CD3 complex engagement, but little is known about the biological consequences of double knockout (dKO) and especially of either single KO (sKO). We elucidated the biological consequences of the lack of

Subject

Animals; Antigen; Colitis/*immunology; Humans; Knockout; Mice; Phosphorylation; Protein Tyrosine Phosphatases/genetics/*physiology; Receptors; T-Cell/genetics/*physiology; T-Lymphocytes/*immunology; ZAP-70 Protein-Tyrosine Kinase/metabolism

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

837–850

Issue

10

Volume

92

Citation

Newman Tiffanny N; Liverani Elisabetta; Ivanova Elitza; Russo Gian L; Carpino Nick; Ganea Doina; Safadi Fayez; Kunapuli Satya P; Tsygankov Alexander Y, “Members of the novel UBASH3/STS/TULA family of cellular regulators suppress,” NEOMED Bibliography Database, accessed July 30, 2021, https://neomed.omeka.net/items/show/3984.

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