Role of prostaglandins in blood-induced vasoconstriction of canine cerebral arteries.

Title

Role of prostaglandins in blood-induced vasoconstriction of canine cerebral arteries.

Creator

Lang S A; Maron M B

Publisher

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Date

1988
1988-02

Description

We tested the hypothesis that the vasoconstriction produced by the application of blood to the adventitial surfaces of the vessels of an isolated perfused canine circle of Willis preparation was mediated by products of prostaglandin metabolism. In this preparation (perfused at constant flow and outflow pressure), topical application of blood produced an average 16.6 +/- 1.8 (SE) mm Hg increase in inflow pressure. This response could be prevented with four structurally dissimilar cyclooxygenase inhibitors (aspirin, indomethacin, ibuprofen, and meclofenamate), suggesting that the blood-induced increase in vascular resistance was mediated by prostaglandins. Imidazole, an inhibitor of thromboxane synthetase, had no effect on the blood response. Further support for the involvement of prostaglandins in this response was provided by additional experiments in which either arachidonic acid, prostaglandin E2 (PGE2), or PGF2 alpha were administered. All three treatments produced vasoconstriction. These results suggest that the vessels of this preparation are capable of synthesizing vasoconstrictor prostaglandins and indicate that they are reactive to known vasoactive prostaglandins.

Subject

*Blood; *Vasoconstriction/drug effects; Animals; Arachidonic Acid; Arachidonic Acids/pharmacology; Aspirin/pharmacology; Cerebral Arteries/drug effects/*physiology; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Dogs; Female; Ibuprofen/pharmacology; Indomethacin/pharmacology; Male; Meclofenamic Acid/pharmacology; Papaverine/pharmacology; Prostaglandins E/pharmacology; Prostaglandins F/pharmacology; Prostaglandins/*physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

109–115

Issue

1

Volume

8

Citation

Lang S A; Maron M B, “Role of prostaglandins in blood-induced vasoconstriction of canine cerebral arteries.,” NEOMED Bibliography Database, accessed May 16, 2021, https://neomed.omeka.net/items/show/3985.

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