Integrated zwitterionic conjugated poly(carboxybetaine thiophene) as a new biomaterial platform.

Integrated zwitterionic conjugated poly(carboxybetaine thiophene) as a new biomaterial platform.

Cao Bin; Tang Qiong; Li Linlin; Lee Chen-Jung; Wang Hua; Zhang Yanqiao; Castaneda Homero; Cheng Gang

Chemical science

2015

2015-01

An integrated zwitterionic conjugated polymer-based biomaterial platform was designed and studied to address some of the key challenges of conjugated polymers in biomedical applications. This biomaterial platform consists of conjugated polymer backbones and multifunctional zwitterionic side chains. Zwitterionic materials gain electrical conductivity and interesting optical properties through conjugated polymer backbones, and non-biocompatible conjugated polymers obtain excellent antifouling properties, enhanced electrical conductivity, functional groups of bioconjugation and response to environmental stimuli via multifunctional zwitterionic side chains. This platform can potentially be adapted to a wide range of applications (e.g. bioelectronics, tissue engineering and biofuel cell), which require high performance conducting materials with excellent antifouling/biocompatibility at biointerfaces.

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