Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.

Title

Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.

Creator

Bishayee Anupam; Haskell Yennie; Do Chau; Siveen Kodappully Sivaraman; Mohandas Nima; Sethi Gautam; Stoner Gary D

Publisher

Critical reviews in food science and nutrition

Date

2016
2016-07

Description

Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as cardiovascular, neurodegenerative, and neoplastic diseases. Berries owe their health benefits to phytoconstituents, such as polyphenolic anthocyanins, ellagic acid, and a diverse array of phytochemicals bestowed with potent antioxidant and anti-inflammatory effects as well as the ability to engage a multitude of signaling pathways. This review highlights the principal chemical constituents present in berries and their primary molecular targets. The article presents and critically analyzes the chemopreventive and therapeutic potential of berry extracts, fractions, and bioactive components on various cancers of the gastrointestinal tract (GIT), including esophageal, stomach, intestinal, and colorectal cancers as well as cancers of the upper aerodigestive tract, such as oral cancer. The current status of clinical studies evaluating berry products in several aforementioned cancers is presented. Various emerging issues including dose-ranging and dosage forms, the role of synergy and the usage of combination therapy as well as other relevant areas essential for the development of berry phytoconstituents as mainstream chemopreventive and therapeutic agents against aerodigestive and GIT cancers are critically discussed.

Subject

aerodigestive and gastrointestinal tract; Animal; Animal Studies; Animals; Anthocyanins/analysis/pharmacology; Anticarcinogenic Agents/*analysis/pharmacology; Antineoplastic Agents – Analysis; Antineoplastic Agents – Pharmacodynamics; Benzopyrans – Analysis; Benzopyrans – Pharmacodynamics; Berry; Biological; cancer; chemoprevention; Clinical Trials; Clinical Trials as Topic; Digestion – Drug Effects; Digestion/drug effects; Disease Models; Ellagic Acid/analysis/pharmacology; Fruit; Fruit/*chemistry; Gastrointestinal Neoplasms – Prevention and Control; Gastrointestinal Neoplasms/*prevention & control; Human; Humans; Models; Phytochemicals – Analysis; Phytochemicals – Pharmacodynamics; Phytochemicals/analysis/pharmacology; Plant Extracts – Analysis; Plant Extracts – Pharmacodynamics; Plant Extracts/*analysis/pharmacology; Polyphenols – Analysis; Polyphenols – Pharmacodynamics; Polyphenols/analysis/pharmacology; treatment

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1753–1775

Issue

10

Volume

56

Citation

Bishayee Anupam; Haskell Yennie; Do Chau; Siveen Kodappully Sivaraman; Mohandas Nima; Sethi Gautam; Stoner Gary D, “Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.,” NEOMED Bibliography Database, accessed January 18, 2022, https://neomed.omeka.net/items/show/4111.

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