Current challenges in dedifferentiated fat cells research.

Title

Current challenges in dedifferentiated fat cells research.

Creator

Shah Mickey; George Richard L; Evancho-Chapman M Michelle; Zhang Ge

Publisher

Organogenesis

Date

2016
2016-07

Description

Dedifferentiated fat cells show great promises as a novel cell source for stem cell research. It has many advantages when used for cell-based therapeutics including abundance, pluripotency, and safety. However, there are many obstacles researchers need to overcome to make the next big move in DFAT cells research. In this review, we summarize the current main challenges in DFAT cells research including cell culture purity, phenotypic properties, and dedifferentiation mechanisms. The common methods to produce DFAT cells as well as the cell purity issue during DFAT cell production have been introduced. Current approaches to improve DFAT cell purity have been discussed. The phenotypic profile of DFAT cells have been listed and compared with other stem cells. Further studies on elucidating the underlying dedifferentiation mechanisms will dramatically advance DFAT cell research.

Subject

*adult stem cells; *Biomedical Research; *Cell Dedifferentiation; *culture purity; *dedifferentiated fat cells; *dedifferentiation; *surface marker; Adipocytes/*cytology; Animals; Cells; Cultured; Humans; Phenotype

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

119–127

Issue

3

Volume

12

Citation

Shah Mickey; George Richard L; Evancho-Chapman M Michelle; Zhang Ge, “Current challenges in dedifferentiated fat cells research.,” NEOMED Bibliography Database, accessed November 27, 2021, https://neomed.omeka.net/items/show/4129.

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