Resveratrol inhibition of Propionibacterium acnes.

Resveratrol inhibition of Propionibacterium acnes.

Docherty John J; McEwen Heather A; Sweet Thomas J; Bailey Erin; Booth Tristan D

The Journal of antimicrobial chemotherapy

2007

2007-06

OBJECTIVES: To evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on Propionibacterium acnes growth. METHODS: Three different strains of P. acnes were tested against resveratrol at concentrations between 0 and 200 mg/L. Piceatannol was included as a second hydroxystilbene to compare with resveratrol, and erythromycin and benzoyl peroxide were used as positive controls. RESULTS: After 24 h of treatment with resveratrol, the average 50% inhibitory concentration (IC(50)) was 73 mg/L and the average 100% inhibitory concentration (IC(100)) was 187 mg/L for the three strains of P. acnes tested. The IC(50) and IC(100) of piceatannol were 123 and 234 mg/L, respectively. The highest concentration of resveratrol tested (200 mg/L) was bactericidal, whereas lower concentrations were bacteriostatic. CONCLUSIONS: Resveratrol, an anti-inflammatory hydroxystilbene, is capable of inhibiting P. acnes growth.

*Anti-Bacterial Agents; Anti-Inflammatory Agents; Benzoyl Peroxide/pharmacology; Dose-Response Relationship; Drug; Erythromycin/pharmacology; Keratolytic Agents/pharmacology; Microbial Sensitivity Tests; Non-Steroidal/*pharmacology; Propionibacterium acnes/*drug effects/growth & development; Resveratrol; Stilbenes/*pharmacology

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